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Alfonso Minicozzi and Family Chair in Thoracic Surgery and Lung Transplantation 

ENDOWED UNIVERSITY CHAIR IN THORACIC SURGERY AND LUNG TRANSPLANTATION

Since its inception in 1997, the University of Montreal lung transplant program has established itself as the second largest program in Canada and among the 15 largest programs in North America. The creation of the Alfonso Minicozzi and Family Chair in Thoracic Surgery and Lung Transplantation provides significant support and helps maintain our objectives in providing the finest care in the field of lung transplantation.
 
However the recruitment of highly qualified academic transplant surgeons remains problematic. At the present time, a single surgeon is responsible for the evaluation and transplantation of all lung transplant patients for the entire Province of Quebec as well as for the assessment of suitable donors for all patients on the waiting list, a task which is not sustainable over the long term.  We believe that the creation of a University Chair with a specific focus on basic scientific research and clinical lung transplantation is necessary to help recruit new surgeons to our team.
 
The Alfonso Minicozzi and Family Chair in Thoracic Surgery and Lung Transplantation will not only ensure the growth and development of the transplant program, but will also provide researchers with the necessary support to help maintain their role as leaders in the field.  Dr. Pasquale Ferraro is the title holder of this Chair.
 
General objectives of the chair:

  • Create a geographic full time university position within our Division at the University of Montreal
     
  • Create the proper environment necessary in the recruitment of academic thoracic surgeons with an expertise in lung transplantation
     
  • Provide constant funding for basic research in the field of lung transplantation
     
  • Sustain the development of the program within our Thoracic Surgery Division at the University of Montreal
     
  • Help support fellowship training for newly recruited transplant surgeons

Specific objectives of the chair:

  • Support basic science research in the area of graft preservation and pulmonary edema
    • preservation techniques and solutions
    • effects of ischemia/reperfusion on both the vascular endothelial cells and the alveolar epithelial cells
    • ischemic pre conditioning and gene therapy
    • cellular and molecular predictive markers of primary graft dysfunction
       
  • Develop and implement an ex vivo lung perfusion (EVLP) program
    • ex vivo assessment of marginal lungs
    • study of inflammatory markers and cytokines
    • improve graft preservation solutions
    • pharmacological intervention to repair damaged lung
       
  • Study the effects of ischemia/reperfusion and graft function in a NHBD (non-heart beating donor) animal model
     
  • Develop a basic science research program in immunosuppression
    • Help test and develop new compounds and immunosuppressive drugs using in vitro and in vivo models
       
  • Study diaphragmatic muscle function and chest wall mechanics in patients with interstitial lung disease before and after lung transplantation